While some observational studies have suggested an association between low serum 25-hydroxyvitamin D levels and an increased risk of cardiovascular disease (CVD) events, a new meta-analysis has concluded that vitamin D supplementation does not confer cardiovascular protection.
Researchers analysed data from 21 randomised controlled trials including 83,291 participants, which examined the association of vitamin D supplementation with reduced CVD events and all-cause mortality. Of these participants, 41,669 had received vitamin D and 41,622 had received placebos.
The study found that compared with placebo, vitamin D supplementation was not associated with reduced major adverse cardiovascular events. A stratified analysis according to age showed a significantly reduced rate of major adverse cardiac events (MACE) with advanced age, but the authors said these findings should be interpreted cautiously owing to lack of adjustment for multiple comparisons. Supplementation was also not associated with myocardial infarction, stroke, CVD mortality, or all-cause mortality.
Presenting the findings in JAMA Cardiology, the authors said additional studies, perhaps targeting members of older age groups may be of interest.