#Treatment of Coronavirus Disease 2019 (COVID-19): Investigational Drugs and Other Therapies

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Coronavirus Travel Advice – How to Avoid Covid-19 while Travelling

Overview

Coronavirus disease 2019 (COVID-19) is defined as illness caused by a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly called 2019-nCoV), which was first identified amid an outbreak of respiratory illness cases in Wuhan City, Hubei Province, China. [1It was initially reported to the World Health Organization (WHO) on December 31, 2019. On January 30, 2020, the WHO declared the COVID-19 outbreak a global health emergency. [23On March 11, 2020, the WHO declared COVID-19 a global pandemic, its first such designation since declaring H1N1 influenza a pandemic in 2009. [4]

No drugs or biologics have been proven to be effective for the prevention or treatment of COVID-19. Numerous antiviral agents, immunotherapies, and vaccines are being investigated and developed as potential therapies. Searching for effective therapies for COVID-19 infection is a complex process. Gordon et al identified 332 high-confidence SARS-CoV-2 human protein-protein interactions. Among these, they identified 66 human proteins or host factors targeted by 69 existing FDA-approved drugs, drugs in clinical trials, and/or preclinical compounds. As of March 22, 2020, these researchers are in the process of evaluating the potential efficacy of these drugs in live SARS-CoV-2 infection assays. [5]

McCreary and Pogue’s “Review of Early and Emerging Options” for COVID-19 treatment provides a comprehensive review of potential beneficial therapies and adjunctive treatments. [6]

An international collaborative publication offers guidance for sepsis management in critically ill adults with COVID-19 and includes evidence-based recommendations.

 

Updated: Mar 27, 2020
  • Author: Scott J Bergman, PharmD, FCCP, FIDSA, BCPS, BCIDP;

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